The Usual Suspects: What Tablets Cause These Risks?
1. Hormonal Contraceptives (Birth Control Pills)
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The Risk: Combined oral contraceptives (which contain both Estrogen and Progestin) are notorious for increasing the risk of blood clots (Deep Vein Thrombosis or DVT), pulmonary embolisms, heart attacks, and strokes.
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Why it happens: Estrogen increases the liver’s production of clotting factors, making the blood “stickier” and more prone to forming dangerous clots.
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Who is at highest risk: Women over 35 who smoke, those with a history of migraines with aura, obesity, or a family history of blood clots.
2. Testosterone Replacement Therapy (TRT) and Anabolic Steroids
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The Risk: Prescription testosterone gels, injections, and especially “black market” bodybuilding tablets can cause the body to produce too many red blood cells (polycythemia).
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Why it happens: When your blood becomes too thick with red blood cells, it cannot pump through your veins easily, dramatically increasing the risk of deep vein thrombosis, heart attacks, and strokes.
3. NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)
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The Risk: Common painkillers like Ibuprofen (Advil/Motrin), Naproxen (Aleve), and especially prescription Diclofenac carry a “Black Box Warning” from the FDA regarding cardiovascular events.
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Why it happens: These drugs block certain enzymes (COX-2) that protect the lining of blood vessels. Long-term or high-dose use can lead to increased blood pressure and a higher risk of heart attack and stroke, even in healthy people.
4. Antifibrinolytics (e.g., Tranexamic Acid / Lysteda)
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The Risk: Used to treat heavy menstrual bleeding.
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Why it happens: These tablets work by preventing blood clots from breaking down. If a person has an underlying clotting disorder, or takes this alongside birth control, the risk of developing dangerous blood clots in the legs, lungs, or brain skyrockets.
5. Certain “Diet” or “Energy” Pills (Stimulants)
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The Risk: Unregulated fat burners or highly concentrated caffeine/ephedra-based tablets.
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Why it happens: Strong stimulants constrict blood vessels, spike blood pressure, and increase heart rate, which can dislodge plaque or trigger a sudden cardiac event.
Warning Signs You Should NEVER Ignore
If you are taking a medication that carries a blood clot or heart attack risk, you need to know the emergency warning signs:
Signs of a Blood Clot (DVT) in the Leg or Arm:
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Swelling in one limb (but not the other)
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Pain or tenderness that feels like a cramp or charley horse
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Skin that is warm to the touch
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Reddish or bluish discoloration of the skin
Signs of a Pulmonary Embolism (Clot traveled to the lungs):
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Sudden shortness of breath
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Sharp chest pain that gets worse when you take a deep breath
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Coughing up blood
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Rapid heart rate or feeling lightheaded
Signs of a Heart Attack:
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Chest pain, pressure, squeezing, or fullness (though women often experience jaw or back pain instead)
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Pain radiating down the left arm
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Cold sweat, nausea, or extreme fatigue
How to Protect Yourself
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Do NOT stop prescribed medication cold turkey. If you read a warning label and are scared, call your pharmacist or doctor first. Stopping some medications (like blood pressure meds or birth control) abruptly can cause its own set of emergencies.
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Get up and move. If you are taking a tablet that increases clot risk (especially birth control or hormones), do not sit for hours on end (like long flights or desk jobs). Flex your ankles and move your legs frequently to keep blood from pooling.
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Know your interactions. Combining smoking with birth control pills, or taking multiple medications that affect clotting, multiples your risk exponentially.
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Check the name. If you saw this warning on a specific viral video or post, look at the exact chemical name on the package and search for the FDA “Black Box Warning” for that specific drug.